# br Boffa DJ Allen MS

52. Boffa DJ, Allen MS, Grab JD, Gaissert HA, Harpole DH, Wright CD. Data from the Society of Thoracic Surgeons general thoracic surgery database: the surgical management of primary lung tumors. J Thorac Cardiovasc Surg. 2008;135: 247-54.

53. Stokes WA, Bronsert MR, Meguid RA, Blum MG, Jones BL, Koshy M, et al. Post-treatment mortality after surgery and stereotactic body radiotherapy for early-stage non-small-cell lung cancer. J Clin Oncol. 2018;36:642-51.

56. Rosenbaum P, Rubin D. Reducing bias in observational studies using subclassification on the propensity score. J Am Stat Assoc. 1984;79:516-24.

57. Lunt M. Selecting an appropriate caliper can be essential for achieving good balance with propensity score matching. Am J Epidemiol. 2014;179: 226-35.

Key Words: stereotactic body MF498 therapy, surgery, nonâ€“small cell lung cancer, survival, meta-analysis

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The Journal of Thoracic and Cardiovascular Surgery c Volume 157, Number 1 373

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Thoracic: Lung Cancer: Review Cao et al

Identification

Records identified through

Additional records identified

database searching

through other sources

Screening

Records after duplicates

removed

Records screened

Records excluded as case

reports, comments, letters,

reviews, or irrelevant papers

Eligibility

Full-text articles assessed

Articles excluded after

for eligibility

applying selection criteria

Included

Studies included in

Removal of overlapping or

systematic review

incomplete reports

Studies included for

quantitative meta-analysis

FIGURE E1. PRISMA flow chart summarizing the literature search strategy in the systematic review of SBRT versus surgical resection for patients with early-stage NSCLC.

Odds Ratio
Odds Ratio

Study or Subgroup
log [Odds Ratio]
SE
Weight
IV, Random,
95% CI
IV, Random, 95% CI

Favours [SBRT]

Favours [surgery]

FIGURE E2. Forest plot of the OR of overall survival in unmatched patients after SBRT versus lobectomy in patients with early-stage NSCLC. The estimate of the OR of each study corresponds to the middle of the squares, and the horizontal line shows the 95% CI. On each line, the numbers of events as a fraction of the total number randomized are shown for both treatment groups. For each subgroup, the sum of the statistics, along with the summary OR, is represented by the middle of the solid diamonds. A test of heterogeneity between the trials within a subgroup is given below the summary statistics. SE, Standard error; CI, confidence interval; SBRT, stereotactic body radiation therapy.

373.e1 The Journal of Thoracic and Cardiovascular Surgery c January 2019

Cao et al Thoracic: Lung Cancer: Review

Odds Ratio

Odds Ratio

Study or Subgroup
log [Odds Ratio]
SE
Weight
IV, Random,
95% CI
IV, Random, 95% CI

Favours [SBRT]

Favours [surgery]

FIGURE E3. Forest plot of the OR of overall survival in matched patients after SBRT versus lobectomy in patients with early-stage NSCLC. The estimate of the OR of each study corresponds to the middle of the squares, and the horizontal line shows the 95%CI. On each line, the numbers of events as a fraction of the total number randomized are shown for both treatment groups. For each subgroup, the sum of the statistics, along with the summary OR, is represented by the middle of the solid diamonds. A test of heterogeneity between the trials within a subgroup is given below the summary statistics. SE, Standard error; CI, confidence interval; SBRT, stereotactic body radiation therapy.

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