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Key Words: stereotactic body MF498 therapy, surgery, non–small cell lung cancer, survival, meta-analysis 
THOR
The Journal of Thoracic and Cardiovascular Surgery c Volume 157, Number 1 373
THOR  Thoracic: Lung Cancer: Review Cao et al
Identification
Records identified through
Additional records identified
database searching
through other sources
Screening
Records after duplicates
removed
Records screened
Records excluded as case
reports, comments, letters,
reviews, or irrelevant papers
Eligibility
Full-text articles assessed
Articles excluded after
for eligibility
applying selection criteria
Included
Studies included in
Removal of overlapping or
systematic review
incomplete reports
Studies included for
quantitative meta-analysis
FIGURE E1. PRISMA flow chart summarizing the literature search strategy in the systematic review of SBRT versus surgical resection for patients with early-stage NSCLC.
Odds Ratio Odds Ratio
Study or Subgroup log [Odds Ratio] SE Weight IV, Random, 95% CI IV, Random, 95% CI
Favours [SBRT]
Favours [surgery]
FIGURE E2. Forest plot of the OR of overall survival in unmatched patients after SBRT versus lobectomy in patients with early-stage NSCLC. The estimate of the OR of each study corresponds to the middle of the squares, and the horizontal line shows the 95% CI. On each line, the numbers of events as a fraction of the total number randomized are shown for both treatment groups. For each subgroup, the sum of the statistics, along with the summary OR, is represented by the middle of the solid diamonds. A test of heterogeneity between the trials within a subgroup is given below the summary statistics. SE, Standard error; CI, confidence interval; SBRT, stereotactic body radiation therapy.
373.e1 The Journal of Thoracic and Cardiovascular Surgery c January 2019
Cao et al Thoracic: Lung Cancer: Review
Odds Ratio
Odds Ratio
Study or Subgroup log [Odds Ratio] SE Weight IV, Random, 95% CI IV, Random, 95% CI
Favours [SBRT]
Favours [surgery]
FIGURE E3. Forest plot of the OR of overall survival in matched patients after SBRT versus lobectomy in patients with early-stage NSCLC. The estimate of the OR of each study corresponds to the middle of the squares, and the horizontal line shows the 95%CI. On each line, the numbers of events as a fraction of the total number randomized are shown for both treatment groups. For each subgroup, the sum of the statistics, along with the summary OR, is represented by the middle of the solid diamonds. A test of heterogeneity between the trials within a subgroup is given below the summary statistics. SE, Standard error; CI, confidence interval; SBRT, stereotactic body radiation therapy. 
THOR