br Contents lists available at ScienceDirect br Internationa
Contents lists available at ScienceDirect
International Journal of Hygiene and
journal homepage: www.elsevier.com/locate/ijheh
Cancers in France in 2015 attributable to occupational exposures
Claire Marant Micallefa,∗, Kevin D. Shielda, Jérôme Vignata, Isabelle Baldib, Barbara Charbotelc, Béatrice Ferversd, Anabelle Gilg Soit Ilge, Pascal Guénelf, Ann Olssong, Lesley Rushtonh,
Sally J. Hutchingsi, Enora Cléroj, Dominique Laurierj, Pascale Scanﬀj, Freddie Braya, Kurt Straifk, Isabelle Soerjomatarama
a Section of Cancer Surveillance, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon, CEDEX 08, France
b Equipe Santé Environnement, Centre de recherche INSERM U 897, Université de Bordeaux, Bât. ISPED - Case 11, 146, rue Léo-Saignat, Bordeaux, France
c Université Lyon 1, UMRESTTE, UMR_T9405, Service des maladies professionnelles, Hospices Civils de Lyon, 8, avenue Rockefeller, 69008, Lyon, France
d Centre Léon Bérard, Université de Lyon, Département cancer environnement, 28 rue Laennec, 69008, Lyon, France
e Santé publique France, Direction Santé Travail, 12, rue du Val d'Osne, 94 415, Saint-Maurice cedex, France
f Centre de recherche en Epidémiologie et Santé des Populations (CESP), Cancer and Environment team, Université Paris-Sud, Université Paris-Saclay, 16, avenue Paul Vaillant Couturier, 94800, Villejuif, France g Section of Environment and Radiation, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon, CEDEX 08, France
h Department of Epidemiology and Biostatistics, Imperial College London, Level 2, Faculty Building, South Kensington Campus, London, SW7 2AZ, United Kingdom
i Manchester University, Population Health, Health Services Research & Primary Care, School of Health Sciences, University of Manchester, Oxford Road, Manchester, M13 9PL, UK
j Direction of Health and Environment, Institute for Radiological Protection and Nuclear Safety, 31, avenue de la Division Leclerc 92260, Fontenay-aux-Roses, 92260, France k Section of Evidence Synthesis and Classification, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon, CEDEX 08, France
Comparative risk assessment/attributable fractions
Background: Recent and comprehensive estimates for Micafungin number of new cancer cases in France attributable to occupational exposures are lacking.
Objectives: To estimate the number of new cancer cases attributable to occupational exposures, using a newly developed methodology and the most recent data, for a comprehensive set of occupational carcinogens in France in 2015.
Methods: Surveys among employees, the national labor force data, a cohort of agricultural workers, national monitoring of workers exposed to ionizing radiation and job-exposure matrix in France were used. The number and proportion of new cancer cases attributable to established occupational carcinogens (Group 1) was esti-mated using estimation of lifetime exposure and risk estimates from cohort studies. Cancer data were obtained from the French Cancer Registries Network.
Results: In France in 2015, an estimated 7905 new cancer cases, 7336 among men and 569 among women, were attributable to occupational exposures, representing 2.3% of all new cancer cases (3.9% and 0.4% among men and women respectively). Among men and women, lung cancer was impacted the most, followed by mesothe-lioma and bladder cancer in men, and by mesothelioma and ovary in women. These cancers contributed to 89% of the total cancers attributable to occupational carcinogens in men, and to 80% in women. The main con-tributing occupational agent was asbestos among men (45%) and women (60%). Conclusions: Currently, occupational exposures contribute to a substantial burden of cancer in France. Enhanced monitoring and implementation of protective labor policies could potentially prevent a large proportion of these cancers.
∗ Corresponding author. International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon, CEDEX 08, France. E-mail addresses: [email protected] (C. Marant Micallef), [email protected] (K.D. Shield), [email protected] (J. Vignat), [email protected] (I. Baldi), [email protected] (B. Charbotel), [email protected] (B. Fervers), [email protected] (A. Gilg Soit Ilg), [email protected] (P. Guénel), [email protected] (A. Olsson), [email protected] (L. Rushton), [email protected] (S.J. Hutchings), [email protected] (E. Cléro), [email protected] (D. Laurier), pascale.scanﬀ@irsn.fr (P. Scanﬀ), [email protected] (F. Bray), [email protected] (K. Straif), [email protected] (I. Soerjomataram).